Endocrine Abstracts

We report the case of a 49 y.o male with an incidental sphenoidal-sellar tumour discovered during a cerebral CT scan during the workup of a medium to severe SARS COV 2 infection. The cerebral MRI describes an invasive tumour located in the sellar region and sphenoidal sinus – extended around the right optic nerve and into both cavernous sinuses. An emergency biopsy from the sphenoidal extension of the tumour revealed a neuroendocrine tumour. The reported diagnostic was ol...

We report a case of a peripubertal 11 yr old girl with a diagnosis of macroprolactinoma. She was diagnosed 1,5 years before her presentation in our clinic in the context of headache. At the diagnostic, the MRI described a moderate enhancing homogenous mass- of 27/16/14 mm -centred on the diaphragm sellae –extended laterally in the right cavernous sinus in contact with the left optic nerve, anterior in the posterior segment of the olfactory sulcus and inferior to the Meck...

A 60-year lady with a history of thyroidectomy for medullary thyroid presented for her regular follow-up - first presentation in our clinic in Nov 2020 (previous visits to another endocrinology clinic).History: 2005: uretheroplasty for left uretheral hypoplasia January 2017: thyroid ultrasound: a unique left lobe thyroid nodule (1 cm)- basal calcitonin x3 UNL (nr <11.5) and 94 pg/ml calcium stimulated CTN; RET gene - negative for mutations in exons 8...

We report a case of familial clustering of familial hypocalciuric hypercalcemia (FHH) associated with and papillary thyroid carcinoma (PTC). The first presentation in our clinic of one of the patients, female patient, was for severe hypercalcemia. The diagnostic workout for hypercalcemia revealed primary hyperparathyroidism (PHPT) due to a left inferior parathyroid adenoma and undergo surgery. The pathologic report described closely packed chief cells arranged in uniform sheet...

Background: Hypogonadism is common among human immunodeficiency virus (HIV)-infected men. The actual prevalence remains poorly defined and ranges from less than 10% to over 50% in different studies. Secondary hypogonadism is the most common cause of hypogonadism among HIV-infected men. In hypogonadal HIV-infected men, naive of highly active antiretroviral therapy (HAART), around 75% have secondary hypogonadism due to the suppression of gonadotropins by the active inflammation ...

Silent corticotroph adenomas are a distinctive subgroup of nonfunctioning pituitary tumours without biochemical or clinical evidence of Cushing’s disease. They are diagnosed after surgery by positive immunostaining for ACTH. They are usually macroadenomas with more aggressive behaviour. On rare occasions, they transform into active Cushing’s disease, with elevated serum ACTH levels. I report a case of a 44 years old lady I first examined in the postoperative neurosur...

Aim: Procollagen type III N-terminal peptide (P3NP) occurs during type III collagen synthesis. Previous studies about the GH misuse in athletes proved the P3NP as a growth hormone (GH) responsive biomarker. We evaluate the P3NP levels and correlate with IGF1 depending on GH status.Subjects and Methods: We determined P3NP levels in 81 prepubertal children (35 girls) with a mean age of 6.2 y.o [3.37–9.95]. The group consists of 37 subjects with normal...

Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disorder characterized by the development of multiple benign tumors of the nerves and the skin (neurofibromas) and areas of abnormal increased and decreased coloration of the skin. Pheochromocytoma develops in 0.1–5.7% of NF1 patients and plexiform neurofibroma in 30% of NF1 patients. We present a case of a 38-year-old female, without relevant personal, with a familial phenotype suggestive for NF1, evaluated for ...

Aim: Somatic growth results from the generation of new support and connective tissue. Since collagen is the major protein constituent of connective tissue, its synthesis must be a prerequisite for the normal growth. The aim of the study was to determine age-related reference intervals for P3NP, a collagen – formation marker in a group of normal height prepubertal children and to compare to IGF1 levels.Subjects: Forty-three prepubertal children, male...

Turner Syndrome (TS) is defined as the combination of characteristic physical features in phenotypic females and complete or partial absence of the second sex chromosome. Short stature is a constant clinical finding in patients with TS. We report the case of a 18 year old female with TS and normal stature. Primary amenorrhea was the reason for the first clinical presentation. Laboratory evaluation showed hypergonadotropic hypogonadism, low oestrogens and testosterone. A pelvic...